NEW YORK — Researchers have identified two genes, making it clear why only some women are likely to conceive twins and others don’t, in a recent study.
With these results, the team hopes to develop a genetic test to identify women at risk for this condition.
“There’s an enormous interest in twins, and in why some women have twins while others don’t,” said one of the researchers Dorret Boomsma, biological psychologist at Vrije Universiteit (VU) Amsterdam in the Netherlands.
The genes behind this theory have always been the mystery. Although it is known that if a woman’s female relatives have non-identical twins, she is more likely to give birth to twins herself.
“The question is very simple, and our research shows for the first time that we can identify genetic variants that contribute to this likelihood,” Boomsma noted in the findings appeared in the journal American Journal of Human Genetics.
For the study, the international team of researchers aggregated genetic data from twin databases in the Netherlands, Australia, and the US.
The sample totaled 1,980 mothers of fraternal (commonly known as non-identical) twins conceived without fertility treatments and 12,953 controls.
The researchers were looking for genetic variants, shared by mothers with twins that showed a different frequency from those in the control groups.
Once the researchers had identified a handful of candidates, they sent the results to collaborators in Iceland, who crunched the numbers on their own set of 3,597 mothers with twins and 297,348 controls.
Two of the gene variants were replicated in the Icelandic cohort, appearing more often in the mothers with fraternal twins conceived without fertility treatments.
One of the variants, located near a gene called FSHB, is associated with higher levels of follicle-stimulating hormone (FSH).
The second genetic variant, in a gene called SMAD3 involved in cell signalling, probably plays a role in how the ovaries respond to FSH, Cornelis Lambalk, gynecologist at VU Medical Centre Amsterdam, said.
If a woman produces an average level of FSH, but her ovaries are more sensitive to the hormone, she may still release multiple eggs at a time.
“This genetic variant is totally novel and hadn’t been shown before as a candidate gene for twinning,” first author on the study Hamdi Mbarek, geneticist at VU Amsterdam, noted.
Nirmala Panta rape, murder case : Locals protest after wrong suspect paraded
BHIMDUTTANAGAR — Locals who were protesting against the rape and murder of Nirmala Panta of Kanchanpur’s Bhimdatta Municipality, have enforced shutdown in Bhimduttanagar Bazaar on Tuesday, protesting police’s failure to reveal facts behind the murder of 13-year-old girl and parading wrong suspect on Monday.
The District Police Office, organising a press conference on Monday,had made public Dilip Singh Bista (41), of Baghphanta, Bhimdatta Municipality-19 as Nirmala’s murderer.
Locals have shut down the market area stating that police were not being able to make public the true murderer(s) as they are not convinced by the findings of police citing that Bista was mentally unsound, according to the District Police Office.
Transportation has also been halted.
Bista, a resident of Khanna Chauraha area in Bhimdutta Municipality-19, was apprehended near the scene of crime on Sunday, according to police.
Police making public the wrong suspect has infuriated the locals and fueled the protest.
The agitators including various civil society organisations and human rights defenders have been picketing the District Administration Office and staging rally on the street mounting pressure on the police to reveal the facts behind the heinous crime.
Meanwhile, it had been learnt that police have fired rounds of teargas shells to contain the agitated mob.
Nirmala was found murdered in a sugarcane field on July 27, a day after she had gone to her friend’s home to get a notebook.Follow @gorkhapost