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Why only fewer women give birth twins, revealed!

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NEW YORK — Researchers have identified two genes, making it clear why only some women are likely to conceive twins and others don’t, in a recent study.

With these results, the team hopes to develop a genetic test to identify women at risk for this condition.

“There’s an enormous interest in twins, and in why some women have twins while others don’t,” said one of the researchers Dorret Boomsma, biological psychologist at Vrije Universiteit (VU) Amsterdam in the Netherlands.

The genes behind this theory have always been the mystery. Although it is known that if a woman’s female relatives have non-identical twins, she is more likely to give birth to twins herself.

“The question is very simple, and our research shows for the first time that we can identify genetic variants that contribute to this likelihood,” Boomsma noted in the findings appeared in the journal American Journal of Human Genetics.

For the study, the international team of researchers aggregated genetic data from twin databases in the Netherlands, Australia, and the US.

The sample totaled 1,980 mothers of fraternal (commonly known as non-identical) twins conceived without fertility treatments and 12,953 controls.

The researchers were looking for genetic variants, shared by mothers with twins that showed a different frequency from those in the control groups.

Once the researchers had identified a handful of candidates, they sent the results to collaborators in Iceland, who crunched the numbers on their own set of 3,597 mothers with twins and 297,348 controls.

Two of the gene variants were replicated in the Icelandic cohort, appearing more often in the mothers with fraternal twins conceived without fertility treatments.

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One of the variants, located near a gene called FSHB, is associated with higher levels of follicle-stimulating hormone (FSH).

The second genetic variant, in a gene called SMAD3 involved in cell signalling, probably plays a role in how the ovaries respond to FSH, Cornelis Lambalk, gynecologist at VU Medical Centre Amsterdam, said.

If a woman produces an average level of FSH, but her ovaries are more sensitive to the hormone, she may still release multiple eggs at a time.

“This genetic variant is totally novel and hadn’t been shown before as a candidate gene for twinning,” first author on the study Hamdi Mbarek, geneticist at VU Amsterdam, noted.

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HOTC sees remarkable success rate on kidney transplant

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HOTC sees remarkable success rate on kidney transplant

BHAKTAPUR — Shahid Dharmabhakta National Human Organ Transplant Centre (HOTC), Bhaktapur has successfully undertaken transplant of over 400 kidneys.

Hospital’s Executive Director Dr Pukar Chandra Shrestha, at a press conference organised here on Friday, informed that the Centre has so far successfully transplanted kidneys on 404 patients.

The Centre had initiated the kidney transplant service on January 19, 2013.

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The inflow of patients has alarmingly increased at the facility with the start of additional medical services such as urology, gastro surgery, cardio therapy, stone removal surgery along with other surgeries, besides kidney transplant, said Prof Dr Rakesh Verma.

However, the patients are compelled to wait for the transplant for long due to limited building space and availability of beds.

Right now, around 400 patients are waiting their turns for kidney transplant and more than this number are waiting to avail of dialysis service.

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