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Study links blood pressure to early life changes in brain activity, blood flow

Raghu Kshitiz

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Unhealthy gut bacteria may also hike blood pressure

WASHINGTON —  Abnormally high blood pressure is linked to changes in brain activity and blood flow early in life, according to a study conducted on a rat model of high blood pressure.

High blood pressure — which is also often called the silent killer because it typically has no symptoms until after it has done significant damage to the heart and the arteries — is a condition in which the force of the blood against the artery walls is too high.

For the study, published in Experimental Physiology, the team investigated physiological changes in a rat model called ISIAH, short for inherited stress-induced arterial hypertension.

High blood pressure — in 90-95 per cent of people — has no identifiable cause, yet it is a risk factor for diseases of the brain, kidneys, heart, eyes, and other parts of the body, said a group of researchers at the Institute of Cytology and Genetics in Russia.

These rats develop high blood pressure at four to six weeks of age, and this is sustained throughout their lifetime.

“The study of early physiological changes may help clarify the cause of high blood pressure. Understanding this could help us prevent the disease early on,” said led author Alisa Seryapina from the Institute of Cytology and Genetics.

As the rats in high blood pressure group grew older, changes in rates of blood flow in certain arteries were observed.

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Type 2 diabetes early in life found to increase risk of fatal heart disease by 60 pc

Gorkha Post

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KATHMANDU — Developing Type 2 diabetes early in life increases risk of death linked to heart disease by 60 percent, according to a study published in Diabetologia.

The condition was once considered a disease of the elderly but the obesity epidemic has led to a surge in cases in young adults and even children too.

Research on 744,000 sufferers over 15 years to 2011 found the average diagnosis age was 59 and there were 115,363 deaths during the period.

It was associated with a 60 percent higher relative risk of dying from heart disease or stroke. Not only that, it was linked to almost a 30 percent higher risk of death from any cause, though a lower risk of dying from cancer was seen.

“Type 2 diabetes in young people is somewhat aggressive and leads to higher mortality,” said study co-author Dianna Magliano, head of the diabetes and population health laboratory at the Baker Heart and Diabetes Institute in Melbourne, Australia.

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Dr Joel Zonszein, director of the Clinical Diabetes Center at Montefiore Medical Center in New York City, said “Type 2 diabetes has evolved through the years into a different type of disease. It used to be a disease of the elderly.” He was not involved with the study.

“What we see nowadays with Type 2 diabetes is that it’s affecting a younger population and is more aggressive. There’s more weight, more lipotoxicity, more insulin resistance and more inflammation, and inflammation can cause premature cardiovascular disease,” Zonszein said.

Lipotoxicity is when the fats in the blood, or cholesterol, build up in places they shouldn’t, such as the liver, kidneys or heart.

The researchers also think the reason the younger people had fewer cancers is that it’s just more common for older people to have cancer.

They also suggested that because this group of younger people is being treated for Type 2 diabetes, it’s possible that when they do have cancer, it’s getting diagnosed and treated sooner, because they’re already engaged in the health care system.

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