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Regular exercise may help people with heart disease in family

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NEW YORK — Regular daily exercise may not only rev up your fitness levels, but it may also significantly cut down risk of heart diseases that could be running in your family, according to the researchers.

Greater grip strength, more physical activity and better cardiorespiratory fitness are associated with reduced risk for heart attacks and stroke — even among people with a genetic pre-disposition for heart disease, researcher said in the the findings published in the American Heart Association’s journal Circulation.

The researchers, for the study, looked at data from roughly a half-million people in the UK Biobank database. For participants with an intermediate genetic risk for cardiovascular diseases, it was revealed that those with the strongest grips were 36 per cent less likely to develop coronary heart disease and had a 46 per cent reduction in their risk for atrial fibrillation, compared to study participants with the same genetic risk who had the weakest grips.

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“The main message is that being physically active is associated with a lower risk of heart disease, even if you have a high genetic risk,” said Erik Ingelsson, lead study author and Professor of Medicine at Stanford University’s School of Medicine in California.

To reach this conclusion, researchers looked at data from roughly a half-million people in the UK Biobank database.

“The main message is that being physically active is associated with a lower risk of heart disease, even if you have a high genetic risk,” said Erik Ingelsson, lead study author and Professor of Medicine at Stanford University’s School of Medicine in California.

Among individuals deemed at high genetic risk for cardiovascular diseases, high levels of cardiorespiratory fitness were associated with a 49 per cent lower risk for coronary heart disease and a 60 per cent lower risk for atrial fibrillation compared to study participants with low cardiorespiratory fitness.

“The study is not a prescription for a specific type or amount of exercise and because the results come from an observational study, Ingelsson said, adding that “we can’t definitely claim a causal connection.”

Nonetheless, the researchers said the data is robust and the results are worthy for consideration in guidelines.

With Agency Inputs

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Diabetes drug might ease heart failure risk

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A new research has showed that the diabetes drug Farxiga might do double-duty for patients, helping to ward off another killer, heart failure.

According to the findings were published in the New England Journal of Medicine to coincide with their presentation at the annual meeting of the American Heart Association in Chicago, Type 2 diabetics who took Farxiga saw their odds of hospitalization for heart failure drop by 27 percent compared to those who took a placebo.

Farxiga is a type of drug called a SGLT2 inhibitor. The compound is called dapagliflozin.

The study included more than 17,000 type 2 diabetes patients aged 40 and older. Nearly 7,000 had heart disease and more than 10,000 had numerous risk factors for heart disease, Wiviott’s group said.

Patients were randomly assigned to take a dummy placebo pill or 10 milligrams of Farxiga each day.

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“When it comes to helping our patients control and manage blood glucose, the ‘how’ appears to be as important [as] the ‘how much,” said study author Dr Stephen Wiviott, a cardiovascular medicine specialist at Brigham and Women’s Hospital in Boston.

“When choosing a therapy, trial results like these can help us make an informed decision about what treatments are not only safe and effective for lowering blood glucose but can also reduce risk of heart and kidney complications,” Wiviott said in a hospital news release.

Taking the drug did not reduce the risk of heart attack, stroke and cardiovascular-related death, the research team noted. However, patients who took the drug did see healthy declines in their blood sugar levels, plus an added bonus: a 27 percent decrease in their risk of hospitalization for heart failure.

Their risk of kidney failure and death from kidney failure also fell, researchers noted.

Two other recent studies of this class of drugs show that they “robustly and consistently improve heart and kidney outcomes in a broad population of patients with diabetes,” Wiviott noted.

With Inputs from HealthDay

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