Men with platelets that don’t convey the Y chromosome are at more serious danger of being determined to have Alzheimer’s ailment, as indicated by another study.
These new discoveries by scientists at Uppsala University could lead to a simple test to identify those at risk of developing Alzheimer’s disease.
Professors Lars Forsberg and Jan Dumanski, from the Department of Immunology, Genetics and Pathology at Uppsala University, and colleagues from Sweden, France, the UK, the US and Canada, investigated loss of the Y chromosome in over 3200 men with an average age of 73, and an age range of 37-96.
The loss of the Y chromosome (LOY) is known not up to 20 percent of men who are aged over 80, and is the most common genetic mutation acquired during a man’s lifetime.
Around 17 percent of them showed LOY in blood cells, and this increased with age. The researchers found that those with an existing diagnosis of Alzheimer’s disease (AD) had a higher degree of LOY, and that LOY was also a marker for the likelihood of developing the disease during the follow-up period.
‘The idea for this research project came to me when I was writing our first paper on the relationship between LOY and the development of non-blood cancers. In thinking about the process known as immunosurveillance – the body’s ability to fight disease development throughout life – I found that it had been well studied in AD, and hence it occurred to me that LOY might be involved in this disease too,’ says Lars Forsberg.
Using standard molecular techniques, the identification of LOY in blood is easy to determine when it occurs in 10 percent or more of blood cells with a nucleus containing DNA. As well as being relatively common in older men, it also occurs less frequently in those who are younger.
Since women do not carry a Y chromosome, and men have, on average, shorter lives, it is possible that LOY may be related to the earlier death of men. However, the researchers say, the mechanisms and causes for their findings are still not properly understood.
They are currently investigating the functional effects of LOY, and looking at its role in different groups of men and in other diseases, in order to understand better which types of cancer are associated with LOY, as well as whether there is a link with early signs of dementia, for example mild cognitive impairment.
‘The blood cells we studied are involved in the immune system, and the fact that LOY in them is associated with disease in other tissues is striking. We therefore hypothesise that the loss of LOY in blood cells leads them to lose part of their immune function,’ says Jan Dumanski.
Previous research by the same group has shown that smoking greatly increases the risk of acquiring LOY, by as much as 400 percent. However, smoking appears to have a transient effect, and is also dose-dependent, so quitting could reverse the effect. This could be important to emphasise in smoking-cessation programmes, the researchers say.
The results are presented in American Journal of Human Genetics.Follow @gorkhapost
2 injured as bomb goes off at Ward Chair’s house
DAMAK — An unidentified group detonated a bomb at the house of Bhim Poudel, a Ward Chairperson of the Damak Municipality Ward Number 7, last night, injuring two people including a woman.
The injured were hit by shrapnel due to the explosion. The explosion has also caused minor damages to the house which is located some 500 metres to the east of the Area Police Office, Damak.
It was a powerful explosion and it is not known who carried it out, police said.
Those injured in the incident are Semu Rai and Tilochan Pokhrel who had come to visit their relatives at the house next to Poudel’s house.
Both them who have been wounded in the hands and legs are being treated at the Lifeline Hospital in Damak. Rai is a staff at the same hospital.
Police has started an investigation into the case. Meanwhile, the Nepal Communist Party led by Netra Bikram Chand (Biplav) has today issued a press release saying those playing main role in evicting the landless squatters in the disputed market area in Damak. It had specifically named Wrad Chair Poudel and Mayor Romnath Oli.
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