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Kidney disease may up risk of diabetes

Raghu Kshitiz

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Kidney disease may up risk of diabetes. Representational image.

KATHMANDU — It is known that diabetes increase a person’s risk of kidney disease. But, now a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true which means Kidney dysfunction also increases the risk of diabetes.

The researchers deduced that a likely culprit of the two-way relationship between kidney disease and diabetes is urea. The risk may be attributed to the rising level of urea — the nitrogen-containing waste product in blood, which comes from the breakdown of protein in foods.

“We have known for a long time that diabetes is a major risk factor for kidney disease, but now we have a better understanding that kidney disease, through elevated levels of urea, also raises the risk of diabetes,” said the Ziyad Al-Aly, Assistant Professor at the Washington University in St. Louis.

The nitrogen-containing waste product in blood comes from the breakdown of protein in foods. Kidneys normally remove urea from the blood, but it can build up when kidney function slows down.

Kidneys normally remove urea from the blood, but it can build up when kidney function slows down, resulting in greater insulin resistance as well as secretion in the body.

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“When urea builds up in the blood because of kidney dysfunction, it often results in increased insulin resistance and impaired insulin secretion,” Ziyad added.

The findings are significant because urea levels can be lowered through medication, diet — for example, by eating less protein — and other means, thereby allowing for improved treatment and possible prevention of diabetes, the researchers said.

For the study, the team evaluated the records of 1.3 million adults without diabetes over a five-year period, beginning in 2003.

Out of these, 117,000 of those without diabetes — or 9 per cent — had elevated urea levels, signalling poor kidney function and were at 23 per cent higher risk of developing diabetes .

The study, conducted in collaboration with the Veterans Affairs St. Louis Health Care System, is published December 11 in Kidney International journal.

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Health

Red meat, white bread and sugar-laden drinks might increase risk of colon cancer

Raghu Kshitiz

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Heavy diet like red meats, refined grains, white bread and sugar-laden drinks might increase long-term risk of colon cancer, a new study suggests.

These foods all increase inflammation in our body, and the inflammation they cause is associated with a higher chance of developing colon cancer, according to pooled data from two major health studies appeared in JAMA Oncology journal.

According to researchers, a diet high in foods with the potential to cause inflammation, including meats, refined grains and high-calorie beverages, was associated with increased risk of developing colorectal cancer for men and women.

Basically, what makes for a healthy diet overall also appears to promote a cancer-free colon, said senior researcher Dr. Edward Giovannucci. He is a professor of nutrition and epidemiology at Harvard TH Chan School of Public Health in Boston.

“It’s consistent with what we already recommend for a healthy diet in general,” Giovannucci said, adding “I see that as good news. We’re supporting the current evidence, and not telling people to do something completely different from what they’ve been told.”

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For the study, conducted by Fred K Tabung from the Harvard TH Chan School of Public Health in Boston, the team analysed 1,21,050 male and female health care professionals, who were followed for 26 years in long-term studies. The researchers completed the food questionnaires about what they ate, on the basis of which data analysis was done last year.

The scores were based on 18 food groups characterised for their inflammatory potential and were then calculated from the questionnaires given to participants every four years.

The results indicated that higher scores reflecting inflammation-causing diets were associated with a higher risk of developing colorectal cancer in men and women.

Previous studies have linked diet factors with colon cancer, but there’s been no clear explanation why that might be, he added.

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