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Kidney disease may up risk of diabetes

Raghu Kshitiz

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Kidney disease may up risk of diabetes. Representational image.

KATHMANDU — It is known that diabetes increase a person’s risk of kidney disease. But, now a new study from Washington University School of Medicine in St. Louis suggests that the converse also is true which means Kidney dysfunction also increases the risk of diabetes.

The researchers deduced that a likely culprit of the two-way relationship between kidney disease and diabetes is urea. The risk may be attributed to the rising level of urea — the nitrogen-containing waste product in blood, which comes from the breakdown of protein in foods.

“We have known for a long time that diabetes is a major risk factor for kidney disease, but now we have a better understanding that kidney disease, through elevated levels of urea, also raises the risk of diabetes,” said the Ziyad Al-Aly, Assistant Professor at the Washington University in St. Louis.

The nitrogen-containing waste product in blood comes from the breakdown of protein in foods. Kidneys normally remove urea from the blood, but it can build up when kidney function slows down.

Kidneys normally remove urea from the blood, but it can build up when kidney function slows down, resulting in greater insulin resistance as well as secretion in the body.

“When urea builds up in the blood because of kidney dysfunction, it often results in increased insulin resistance and impaired insulin secretion,” Ziyad added.

The findings are significant because urea levels can be lowered through medication, diet — for example, by eating less protein — and other means, thereby allowing for improved treatment and possible prevention of diabetes, the researchers said.

For the study, the team evaluated the records of 1.3 million adults without diabetes over a five-year period, beginning in 2003.

Out of these, 117,000 of those without diabetes — or 9 per cent — had elevated urea levels, signalling poor kidney function and were at 23 per cent higher risk of developing diabetes .

The study, conducted in collaboration with the Veterans Affairs St. Louis Health Care System, is published December 11 in Kidney International journal.

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Attorney General Kharel directs police to file a case to seek life imprisonment to rapists

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DHANUSA— Attorney General Agni Prasad Kharel has directed the police department to file a case seeking life imprisonment to the men arrested for raping and murdering 10-year-old girl Manika Yadav along with confiscation of all property.

He made this direction to Superintendent of Police Gobinda Thapaliya during an inspection of the office of district government advocate and high government advocate office in Janakpur.

Kharel also met Manika’s family at Aaurahi Rural Municipality.

During the meeting, he assured the bereaved family of action against the rapists and economic help to them.

The Dhanusa police have arrested Binod Mukhiya and Nathuni Pandit from the locality on the charge of raping Manika.

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