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Early breast cancer may identify with urine test

Gorkha Post

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BERLIN — A new test that recognizes changes in cell metabolism system through urine tests may identify breast cancer early, researchers say.

According to the findings, published in the journal BMC Cancer, researchers at the University of Freiburg in Germany have developed a technique that involves determining the concentration of molecules that regulate cell metabolism which are often deregulated in cancer cells.

These molecules, referred to as microRNAs, enter into the urine over the blood. By deciding the structure of microRNAs in the urine, the researchers succeeded in setting up with 91 for percent accuracy whether a test subject was healthy or diseased.

The measurement was possible through the discovery of only four microRNAs.

If the effectiveness of the method is confirmed in further studies, it could serve later on as a method for checking the achievement of treatment and possibly also of making an early determination of breast cancer, researchers said.
Currently, researchers have made breast cancer diagnosis by mammography or ultrasound and confirmed it with tissue tests.

However, these methods have been subject to recurring criticism due to radiation exposure, erroneous results, and the fact that they involve an invasive intervention.

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In the study, Dr Elmar Stickeler, medical director of Senology at the Department of Obstetrics and Gynecology and head of the Breast Center at the Medical Center and his team measured the concentrations of nine microRNAs in the urine, short genetic sequences that regulate cell metabolism.

Four of the nine molecules exhibited significant differences in concentration between healthy and diseased test subjects.

“We discovered that the microRNA profile in the urine is modified in a characteristic way in the urine of test subjects with breast cancer,” said Stickeler.

“MicroRNAs should thus be suitable in principle for a breast cancer test,” Stickeler said.

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Drinking 3 cups of coffee or tea daily may keep stroke risk at bay

Raghu Kshitiz

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KATHMANDU — There have been several conflicting studies on the health benefits of drinking coffee and tea and their various varieties. But drinking up to three cups of coffee or tea in a day is safe because it reduces irregular heartbeat and stroke risk, according to a new study published in the journal JACC: Clinical Electrophysiology.

Coffee has previously been believed to worsen abnormal heart rhythms, as doctors generally discourage patients suffering from the condition. However, the results of this particular study say that a daily consumption of upto 300 mg of caffeine may be safe for arrhythmic patients.

This is because the caffeine acts as a stimulant to the central nervous system and blocks the effect of adenosine. Adenosine is a chemical which causes Atrial Fibrillation (AFib).

A single cup of coffee contains about 95 mg of caffeine. It acts as a stimulant to the central nervous system and works to block the effects of adenosine — a chemical that causes AFib.

AFib is the most common heart rhythm disorder, causes the heart to beat rapidly and skip beats, and if left untreated, can cause strokes.

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“There is a public perception, often based on anecdotal experience, that caffeine is a common acute trigger for heart rhythm problems,” said lead author Peter Kistler, Director at Melbourne’s Alfred Hospital.

But, “caffeinated beverages such as coffee and tea have long-term anti-arrhythmic properties mediated by antioxidant effects and antagonism of adenosine,” he added.

A meta-analysis of 228,465 participants showed that AFib frequency decreasing by 6 per cent in regular coffee drinkers, and an analysis of 115,993 patients showed a 13 per cent reduced risk.

Another study of 103 post-heart attack patients who received an average of 353 mg of caffeine a day showed improvement in heart rate and no significant arrhythmias — or abnormal heart rhythms, that cause the heart to beat too fast, slow or unevenly.

However, in two studies, where patients drank at least 10 cups and nine cups of coffee per day, showed an increased risk for ventricular arrhythmias (VAs) – a condition in which the lower chambers of the heart (ventricles) beat very quickly.

On the other hand, patients with pre-existing heart conditions who consumed two or more energy drinks — that contains concentrated caffeine — per day reported palpitations within 24 hours.

With Agency Inputs

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