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Early breast cancer may identify with urine test

Gorkha Post

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BERLIN — A new test that recognizes changes in cell metabolism system through urine tests may identify breast cancer early, researchers say.

According to the findings, published in the journal BMC Cancer, researchers at the University of Freiburg in Germany have developed a technique that involves determining the concentration of molecules that regulate cell metabolism which are often deregulated in cancer cells.

These molecules, referred to as microRNAs, enter into the urine over the blood. By deciding the structure of microRNAs in the urine, the researchers succeeded in setting up with 91 for percent accuracy whether a test subject was healthy or diseased.

The measurement was possible through the discovery of only four microRNAs.

If the effectiveness of the method is confirmed in further studies, it could serve later on as a method for checking the achievement of treatment and possibly also of making an early determination of breast cancer, researchers said.
Currently, researchers have made breast cancer diagnosis by mammography or ultrasound and confirmed it with tissue tests.

However, these methods have been subject to recurring criticism due to radiation exposure, erroneous results, and the fact that they involve an invasive intervention.

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In the study, Dr Elmar Stickeler, medical director of Senology at the Department of Obstetrics and Gynecology and head of the Breast Center at the Medical Center and his team measured the concentrations of nine microRNAs in the urine, short genetic sequences that regulate cell metabolism.

Four of the nine molecules exhibited significant differences in concentration between healthy and diseased test subjects.

“We discovered that the microRNA profile in the urine is modified in a characteristic way in the urine of test subjects with breast cancer,” said Stickeler.

“MicroRNAs should thus be suitable in principle for a breast cancer test,” Stickeler said.

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Lifestyle increasing cancer

Pratigya Waiju

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KATHMANDU—Smoking, chewing tobacco, poor diet and lack of exercise are the leading risk factor for increasing cancer cases.

Nepal’s two biggest cancer centers, BP Koirala Memorial Cancer Hospital (BPKMCH) in Bharatpur, Chitwan and Bhaktapur cancer Hospital (BCH) in Kathmandu Valley, recorded a total of 19,433 new cases in 2017.

BPKMCH, which started with 100 beds in 2000, recently added 34 new beds, bringing the total number of beds to 228; following a rise in the number of cancer patients.

Lung cancer is the most prevalent cancer among Nepalis, followed by cervix and uteri, breast, stomach, gallbladder, ovary, oesophagus, urinary bladder and thyroid.

Among men, smoking and drinking from early age and chewing tobacco and betel nuts are attributed as the major contributors of Ear, Nose and throat (ENT) cancer.

Both indoor and outdoor pollution are also significant factors affecting people who work in those conditions the most.

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