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E-cigarettes may lead to accumulation of fat in the liver

Gorkha Post

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WASHINGTON — Using e-cigarettes may lead to an accumulation of fat in the liver, a study of mice exposed to the devices suggests.

The research was presented Sunday, March 18, at ENDO 2018, the Endocrine Society’s 100th annual meeting in Chicago, Ill.

“The popularity of electronic cigarettes has been rapidly increasing in part because of advertisements that they are safer than conventional cigarettes. But because extra fat in the liver is likely to be detrimental to health, we conclude that e-cigarettes are not as safe as they have been promoted to consumers,” said lead author Theodore C. Friedman of Charles R. Drew University of Medicine and Science in Los Angeles, Calif. “This has important public health and regulatory implications.”

E-cigarettes contain nicotine, which Dr Friedman and other researchers have reported is associated with non-alcohol fatty liver diseases. However, the long-term effects of e-cigarettes on liver disease, diabetes, heart disease or stroke are unknown.

In the 12-week study, Friedman and colleagues studied mice missing the gene for apolipoprotein E, which makes them more prone to developing heart disease and fat in the liver. All of the mice were fed a diet relatively high in fat and cholesterol.

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One group of mice was put in a chamber that exposed them to e-cigarette aerosol, so that their blood nicotine levels were similar to that of smokers and e-cigarette users. A second group of mice were exposed to saline aerosol.

The researchers collected liver samples, and looked at genes in the liver affected by e-cigarettes using a technique called RNA sequence analysis. They found changes in 433 genes that were associated with fatty liver development and progression in the mice exposed to e-cigarettes.

The researchers also found that genes related to circadian rhythms (the body clock) were changed in mice exposed to e-cigarettes. Circadian rhythm dysfunction is known to accelerate the development of liver disease including fatty liver diseases.

“Our experimental results will provide support to policymakers and federal and state regulatory bodies to take preventive measures to stop the increasing use of e-cigarettes among both children and adults,” Friedman said.

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Health

Drinking 3 cups of coffee or tea daily may keep stroke risk at bay

Raghu Kshitiz

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KATHMANDU — There have been several conflicting studies on the health benefits of drinking coffee and tea and their various varieties. But drinking up to three cups of coffee or tea in a day is safe because it reduces irregular heartbeat and stroke risk, according to a new study published in the journal JACC: Clinical Electrophysiology.

Coffee has previously been believed to worsen abnormal heart rhythms, as doctors generally discourage patients suffering from the condition. However, the results of this particular study say that a daily consumption of upto 300 mg of caffeine may be safe for arrhythmic patients.

This is because the caffeine acts as a stimulant to the central nervous system and blocks the effect of adenosine. Adenosine is a chemical which causes Atrial Fibrillation (AFib).

A single cup of coffee contains about 95 mg of caffeine. It acts as a stimulant to the central nervous system and works to block the effects of adenosine — a chemical that causes AFib.

AFib is the most common heart rhythm disorder, causes the heart to beat rapidly and skip beats, and if left untreated, can cause strokes.

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“There is a public perception, often based on anecdotal experience, that caffeine is a common acute trigger for heart rhythm problems,” said lead author Peter Kistler, Director at Melbourne’s Alfred Hospital.

But, “caffeinated beverages such as coffee and tea have long-term anti-arrhythmic properties mediated by antioxidant effects and antagonism of adenosine,” he added.

A meta-analysis of 228,465 participants showed that AFib frequency decreasing by 6 per cent in regular coffee drinkers, and an analysis of 115,993 patients showed a 13 per cent reduced risk.

Another study of 103 post-heart attack patients who received an average of 353 mg of caffeine a day showed improvement in heart rate and no significant arrhythmias — or abnormal heart rhythms, that cause the heart to beat too fast, slow or unevenly.

However, in two studies, where patients drank at least 10 cups and nine cups of coffee per day, showed an increased risk for ventricular arrhythmias (VAs) – a condition in which the lower chambers of the heart (ventricles) beat very quickly.

On the other hand, patients with pre-existing heart conditions who consumed two or more energy drinks — that contains concentrated caffeine — per day reported palpitations within 24 hours.

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